The berries of cranberry are used since hundreds of years as a remedy for diseases of the urinary tract and have attracted attention due to their potential health benefits. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PAC) with A-type linkages were isolated from cranberry which exhibit bacterial anti-adhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The phytochemicals associated with cranberry bioactivity include flavonoids, phenolic acid derivatives, hydroxycinnamic acid derivatives, organic acids, and isoprenoids (including ursolic acid and lutein). Among phenols are flavonols, anthocyanins and proanthocyanidins (PACs), catechins or flavan-3-ols.
How Cranberry Works
Cranberry acidity rates are beneficial mechanisms that have been proven effective in treating FUS / FIC / FLUTD / UTI problems clinically. High cranberry fruit acidity rates will change the PH urine of the animals and will dissolve coral / crystalline buildup. It also causes bacteriostatic effect where bacterial infection in the urinary tract will die and thereby reducing inflammation in stages.
Supporting clinical study on Zendin ingredient against UTI:
Prevention of Urinary Tract Infection with Oximacro® (active ingredients in Zendin)
A-type cranberry proanthocyanidins
Canine bacterial urinary tract infections
Feline bacterial urinary tract infections
The structure of cranberry proanthocyanidins